A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor CellsS

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 333; no. 2; pp. 454 - 464
• Main Authors: Beljanski, Vladimir, Knaak, Christian, Smith, Charles D.
• Format: Journal Article
• Language: English
• Published: The American Society for Pharmacology and Experimental Therapeutics 01.05.2010
• Subjects: Cellular and Molecular

The sphingolipids ceramide, sphingosine, and sphingosine 1-phosphate (S1P) regulate cell signaling, proliferation, apoptosis, and autophagy. Sphingosine kinase-1 and -2 (SK1 and SK2) phosphorylate sphingosine to form S1P, shifting the balanced activity of these lipids toward cell proliferation. We h...