TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients1

• Published in: The Journal of immunology (1950) Vol. 183; no. 11; pp. 7461 - 7470
• Main Authors: Jagannathan, Madhumita, Hasturk, Hatice, Liang, YanMei, Shin, Hyunjin, Hetzel, Jeremy T., Kantarci, Alpdogan, Rubin, Daniel, McDonnell, Marie E., Van Dyke, Thomas E., Ganley-Leal, Lisa M., Nikolajczyk, Barbara S.
• Format: Journal Article
• Language: English
• Published: 16.11.2009

Chronic systemic inflammation links periodontal disease and diabetes to increased incidence of serious comorbidities. Activation of TLRs, particularly TLR2 and TLR4, promotes chronic systemic inflammation. Human B cells have been generally thought to lack these TLRs. However, recent work showed that...