GPR37 Surface Expression Enhancement via N-Terminal Truncation or Protein-Protein Interactions1

• Published in: Biochemistry (Easton) Vol. 48; no. 43; pp. 10286 - 10297
• Main Authors: Dunham, Jill H., Meyer, Rebecca C., Garcia, Erin L., Hall, Randy A.
• Format: Journal Article
• Language: English
• Published: 03.11.2009

GPR37, also known as the parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR) that exhibits poor plasma membrane expression when expressed in most cell types. We sought to find ways to enhance GPR37 trafficking to the cell surface in order to facilitate...