BRAFV600E Efficient Transformation and Induction of Microsatellite Instability Versus KRASG12V Induction of Senescence Markers in Human Colon Cancer Cells12

In colorectal cancer, BRAF and KRAS oncogenes are mutated in about 15% and 35% respectively at approximately the same stage of the adenoma-carcinoma sequence. Since these two mutations rarely coexist, further analysis to dissect their function of transformation in colon cancer is required. Caco-2 hu...

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Bibliographic Details
Published inNeoplasia (New York, N.Y.) Vol. 11; no. 11; pp. 1116 - 1131
Main Authors Oikonomou, Eftychia, Makrodouli, Eleni, Evagelidou, Maria, Joyce, Tobias, Probert, Lesley, Pintzas, Alexander
Format Journal Article
LanguageEnglish
Published Neoplasia Press Inc 01.11.2009
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