A Genetic Polymorphism in Coumarin 7-Hydroxylation: Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles

• Published in: American journal of human genetics Vol. 57; no. 3; pp. 651 - 660
• Main Authors: Fernandez-Salguero, Pedro, Hoffman, Susan M. G., Cholerton, Suzanne, Mohrenweiser, Harvey, Raunio, Hannu, Rautio, Arja, Pelkonen, Olavi, Huang, Jin-ding, Evans, William E., Idle, Jeffrey R., Gonzalez, Frank J.
• Format: Journal Article
• Language: English
• Published: 01.09.1995
• Subjects: Original

A group of human cytochrome P450 genes encompassing the CYP2A, CYP2B , and CYP2F subfamilies were cloned and assembled into a 350-kb contig localized on the long arm of chromosome 19. Three complete CYP2A genes— CYP2A6, CYP2A7 , and CYP2A13 —plus two pseudogenes truncated after exon 5, were identifi...