Hsp70 Chaperones as Modulators of Prion Life Cycle Novel Effects of Ssa and Ssb on the

• Published in: Genetics (Austin) Vol. 169; no. 3; pp. 1227 - 1242
• Main Authors: Allen, Kim D., Wegrzyn, Renee D., Chernova, Tatiana A., Müller, Susanne, Newnam, Gary P., Winslett, Peggy A., Wittich, Kristin B., Wilkinson, Keith D., Chernoff, Yury O.
• Format: Journal Article
• Language: English
• Published: Genetics Society of America 01.03.2005
• Subjects: Investigations

[PSI + ] is a prion isoform of the yeast release factor Sup35. In some assays, the cytosolic chaperones Ssa1 and Ssb1/2 of the Hsp70 family were previously shown to exhibit “pro-[PSI + ]” and “anti-[PSI + ]” effects, respectively. Here, it is demonstrated for the first time that excess Ssa1 increase...