The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT 2C Receptor

• Published in: European journal of pharmacology p. 177081
• Main Authors: Feng, Chenlin, Liu, Rongfang, Brooks, Reno, Wang, Xuesong, Jespers, Willem, Gorostiola González, Marina, Westen, Gerard J P van, Danen, Erik H J, Heitman, Laura H
• Format: Journal Article
• Language: English
• Published: Netherlands 29.10.2024
• Subjects: G protein-coupled receptor; mutation; serotonin; 5-HT(2C) receptor; cancer

The serotonin 5-HT receptor is a G protein-coupled receptor (GPCR) mainly expressed in the central nervous system. Besides regulating mood, appetite, and reproductive behavior, it has been identified as a potential target for cancer treatment. In this study, we aimed to investigate the effects of ca...