HAF prevents hepatocyte apoptosis and progression to MASH and hepatocellular carcinoma through transcriptional regulation of the NF-κB pathway

• Published in: Hepatology (Baltimore, Md.)
• Main Authors: Acuña-Pilarte, Karen, Reichert, Ethan C, Song Green, Yangsook, Halberg, Lily M-T, Golkowski, Martin, Maguire, Kathleen M, Mimche, Patrice N, Kamdem, Severin Donald, Hu, Po-An, Wright, Jillian, Ducker, Gregory S, Voth, Warren P, O'Connell, Ryan M, McFarland, Sydney A, Egal, Erika Said Abu, Chaix, Amandine, Summers, Scott A, Reelitz, Jordan W, Maschek, J Alan, Cox, James E, Evason, Kimberley J, Koh, Mei Yee
• Format: Journal Article
• Language: English
• Published: United States 10.09.2024

HCC incidence is increasing worldwide due to the obesity epidemic, which drives metabolic dysfunction-associated steatohepatitis (MASH) that can lead to HCC. However, the molecular pathways driving MASH-HCC are poorly understood. We have previously reported that male mice with haploinsufficiency of...