The m 6 A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1870; no. 7; p. 167354
• Main Authors: Zhao, Yiqing, Ding, Wenqian, Cai, Yongjie, Li, Qimeng, Zhang, Wenjie, Bai, Yujia, Zhang, Yiwen, Xu, Qiong, Feng, Zhihui
• Format: Journal Article
• Language: English
• Published: Netherlands 14.07.2024
• Subjects: FTO; Acute lung injury; Ferroptosis; ACSL4; Inflammation; Macrophage

Acute lung injury (ALI) is a serious disorder characterized by the release of pro-inflammatory cytokines and cascade activation of macrophages. Ferroptosis, a form of iron-dependent cell death triggered by intracellular phospholipid peroxidation, has been implicated as an internal mechanism underlyi...