Redox regulation of m 6 A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

• Published in: Nature cell biology Vol. 26; no. 3; p. 421
• Main Authors: De Jesus, Dario F, Zhang, Zijie, Brown, Natalie K, Li, Xiaolu, Xiao, Ling, Hu, Jiang, Gaffrey, Matthew J, Fogarty, Garrett, Kahraman, Sevim, Wei, Jiangbo, Basile, Giorgio, Rana, Tariq M, Mathews, Clayton, Powers, Alvin C, Parent, Audrey V, Atkinson, Mark A, Dhe-Paganon, Sirano, Eizirik, Decio L, Qian, Wei-Jun, He, Chuan, Kulkarni, Rohit N
• Format: Journal Article
• Language: English
• Published: England 01.03.2024

Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that -methyladenosine (m A) is an adaptive β-cell safeguard mechanism that controls the amplitude and duration of the ant...