Recording ten-fold larger I Kr conductances with automated patch clamping using equimolar Cs + solutions

• Published in: Frontiers in physiology Vol. 15; p. 1298340
• Main Authors: Bloothooft, Meye, Verbruggen, Bente, Seibertz, Fitzwilliam, van der Heyden, Marcel A G, Voigt, Niels, de Boer, Teun P
• Format: Journal Article
• Language: English
• Published: Switzerland 2024
• Subjects: Cs; cardiac electrophysiology; hERG; hiPSC-CM; drugs; ion channel; automated patch clamp; conductance

The rapid delayed rectifier potassium current (I ) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately measuring this current can be challenging in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes because of its small...