Structural Basis for coronaviral main proteases Inhibition by a 3CL Protease Inhibitor- GC376
The main protease (M ) of coronaviruses participates in viral replication, serving as a hot target for drug design. GC376 is able to effectively inhibit the activity of M , which is due to nucleophilic addition of GC376 by binding covalently with Cys145 in M active site. Here, we used fluorescence r...
Saved in:
Published in | Journal of molecular biology p. 168474 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
02.02.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!