Hedgehog signalling is involved in acquired resistance to KRAS G12C inhibitors in lung cancer cells

• Published in: Cell death & disease Vol. 15; no. 1; p. 56
• Main Authors: Lee, Chaeyoung, Yi, Jawoon, Park, Jihwan, Ahn, Byungyong, Won, Young-Wook, Jeon, JiHeung, Lee, Byung Ju, Cho, Wha Ja, Park, Jeong Woo
• Format: Journal Article
• Language: English
• Published: England 16.01.2024

Although KRAS inhibitors have shown promising activity in lung adenocarcinomas harbouring KRAS , acquired resistance to these therapies eventually occurs in most patients. Re-expression of KRAS is thought to be one of the main causes of acquired resistance. However, the mechanism through which cance...