Sialyl Lewis X glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites

• Published in: Bioorganic & medicinal chemistry Vol. 98; p. 117553
• Main Authors: Belouin, Audrey, Simard, Ryan D, Joyal, Mathieu, Maharsy, Wael, Lau, Alice, Prévost, Michel, Nemer, Mona, Guindon, Yvan
• Format: Journal Article
• Language: English
• Published: England 15.01.2024
• Subjects: sialyl Lewis(x); Glycomimetics; Selectin; Synthesis; HL-60; Inflammation; PSGL-1; Leukocytes; Neutrophil

Neutrophil binding to vascular P- and E-selectin is the rate-limiting step in the recruitment of immune cells to sites of inflammation. Many diseases, including sickle cell anemia, post-myocardial infarction reperfusion injury, and acute respiratory distress syndrome are characterized by dysregulate...