An alkaloid from Menispermum dauricum, dauricine mediates Ca 2+ influx and inhibits NF-κB pathway to protect chondrocytes from IL-1β-induced inflammation and catabolism

• Published in: Journal of ethnopharmacology Vol. 321; p. 117560
• Main Authors: Xia, Gan-Qing, Zhu, Mei-Peng, Li, Jian-Wen, Huang, Hui
• Format: Journal Article
• Language: English
• Published: Ireland 01.03.2024
• Subjects: Animals; Benzylisoquinolines - pharmacology; Cells, Cultured; Chondrocytes; Humans; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Interleukin-1beta - metabolism; Menispermum - metabolism; Mice; NF-kappa B - metabolism; Osteoarthritis - chemically induced; Osteoarthritis - drug therapy; NF-κB; Chondrocyte; Ca(2+); Inflammation; Dauricine; Osteoarthritis

Dauricine (DA) is a natural plant-derived alkaloid extracted from Menispermum dauricum. Menispermum dauricum has been used in traditional Chinese medicine as a classic remedy for rheumatoid arthropathy and is believed to be effective in alleviating swelling and pain in the limbs. Osteoarthritis (OA)...