Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Jones, Hannah E, Robertson, Gabriella L, Romero-Morales, Alejandra, O'Rourke, Rebecca, Siegenthaler, Julie A, Gama, Vivian
• Format: Journal Article
• Language: English
• Published: United States 02.12.2023

Neural organoids derived from human induced pluripotent stem cells (iPSCs) provide a model to study the earliest stages of human brain development, including neurogenesis, neural differentiation, and synaptogenesis. However, neural organoids lack supportive tissues and some non-neural cell types tha...