Identification and characterization of calreticulin as a novel plasminogen receptor

• Published in: The Journal of biological chemistry Vol. 300; no. 1; p. 105465
• Main Authors: Bharadwaj, Alamelu G, Okura, Gillian C, Woods, John W, Allen, Erica A, Miller, Victoria A, Kempster, Emma, Hancock, Mark A, Gujar, Shashi, Slibinskas, Rimantas, Waisman, David M
• Format: Journal Article
• Language: English
• Published: United States 17.11.2023
• Subjects: plasminogen; plasminogen regulation; tissue plasminogen activator; plasmin; calreticulin

Calreticulin (CRT) was originally identified as a key calcium-binding protein of the endoplasmic reticulum. Subsequently, CRT was shown to possess multiple intracellular functions, including roles in calcium homeostasis and protein folding. Recently, several extracellular functions have been identif...