Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

• Published in: Research square
• Main Authors: Smith, Kirk, Deutsch, Aaron J, McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H, Westerman, Kenneth E, Szczerbinski, Lukasz, Majarian, Timothy D, Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C, Manning, Alisa K, Mercader, Josep M, Gaulton, Kyle J, Udler, Miriam S
• Format: Journal Article
• Language: English
• Published: United States 09.10.2023

We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T2D subtypes with distinct cardiometabolic trait associations....