Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotype

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Payea, Matthew J, Dar, Showkat A, Anerillas, Carlos, Martindale, Jennifer L, Belair, Cedric, Munk, Rachel, Malla, Sulochan, Fan, Jinshui, Piao, Yulan, Yang, Xiaoling, Rehman, Abid, Banskota, Nirad, Abdelmohsen, Kotb, Gorospe, Myriam, Maragkakis, Manolis
• Format: Journal Article
• Language: English
• Published: United States 18.11.2023

Senescence is a state of indefinite cell cycle arrest associated with aging, cancer, and age-related diseases. Here, using label-based mass spectrometry, ribosome profiling and nanopore direct RNA sequencing, we explore the coordinated interaction of translational and transcriptional programs of hum...