PBPK modeling for drug dosing in pediatric patients: a tutorial for a pragmatic approach in clinical care

• Published in: Clinical pharmacology and therapeutics
• Main Authors: van der Heijden, Joyce E M, Freriksen, Jolien J M, de Hoop-Sommen, Marika A, Greupink, Rick, de Wildt, Saskia N
• Format: Journal Article
• Language: English
• Published: United States 08.08.2023

It is well accepted that off-label drug dosing recommendations for pediatric patients should be based on the best available evidence. However, the available traditional evidence is often low. To bridge this gap, physiologically-based pharmacokinetic (PBPK) modeling is a scientifically well-founded t...