Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Lin, Yan, Jung, Hyeim, Bulman, Christina A, Ng, James, Vinck, Robin, O'Beirne, Cillian, Moser, Matthew S, Tricoche, Nancy, Peguero, Ricardo, Li, Robert W, Urban, Joseph F, Pape, Patrice Le, Pagniez, Fabrice, Moretto, Marco, Weil, Tobias, Lustigman, Sara, Cariou, Kevin, Mitreva, Makedonka, Sakanari, Judy A, Gasser, Gilles
• Format: Journal Article
• Language: English
• Published: United States 30.06.2023

Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic parasitic pathogens including fungal infections. Since these diseases target the most vulnerable communities who ar...