H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas

• Published in: bioRxiv
• Main Authors: Garcia-Fabiani, Maria B, Haase, Santiago, Banerjee, Kaushik, McClellan, Brandon, Zhu, Ziwen, Mujeeb, Anzar, Li, Yingxiang, Yu, Jin, Kadiyala, Padma, Taher, Ayman, Núñez, Felipe J, Alghamri, Mahmoud S, Comba, Andrea, Mendez, Flor M, Nicola Candia, Alejandro J, Salazar, Brittany, Koschmann, Carl, Nunez, Fernando M, Edwards, Marta, Qin, Tingting, Sartor, Maureen A, Lowenstein, Pedro R, Castro, Maria G
• Format: Journal Article
• Language: English
• Published: United States 13.06.2023

Pediatric high-grade gliomas (pHGGs) are diffuse and highly aggressive CNS tumors which remain incurable, with a 5-year overall survival of less than 20%. Within glioma, mutations in the genes encoding the histones H3.1 and H3.3 have been discovered to be age-restricted and specific of pHGGs. This w...