Distinct Local and Global Functions of Aβ Low-Threshold Mechanoreceptors in Mechanical Pain Transmission

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Gautam, Mayank, Yamada, Akihiro, Yamada, Ayaka I, Wu, Qinxue, Kridsada, Kim, Ling, Jennifer, Yu, Huasheng, Dong, Peter, Ma, Minghong, Gu, Jianguo, Luo, Wenqin
• Format: Journal Article
• Language: English
• Published: United States 18.05.2023

The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics, and high-speed imaging to specifically examine functions of...