A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Shaku, Moagi T, Um, Peter, Ocius, Karl L, Apostolos, Alexis J, Pires, Marcos M, Bishai, William R, Kana, Bavesh D
• Format: Journal Article
• Language: English
• Published: United States 03.05.2023

Mechanisms by which (Mtb) evades pathogen recognition receptor activation during infection may offer insights for the development of improved tuberculosis (TB) vaccines. Whilst Mtb elicits NOD-2 activation through host recognition of its peptidoglycan-derived muramyl dipeptide (MDP), it masks the en...