NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Feng, Wei, Beer, Joanne, Hao, Qinyu, Ariyapala, Ishara S, Sahajan, Aparna, Komarov, Andrei, Cha, Katie, Moua, Mason, Qiu, Xiaolei, Xu, Xiaomei, Iyengar, Shweta, Yoshimura, Thu, Nagaraj, Rajini, Wang, Li, Yu, Ming, Engel, Kate, Zhen, Lucas, Xue, Wen, Lee, Chen-Jung, Park, Chan Ho, Peng, Cheng, Zhang, Kaiyuan, Grzybowski, Adrian, Hahm, Johnnie, Schmidt, Susanne V, Odainic, Alexandru, Spitzer, Jasper, Buddika, Kasun, Kuo, Dwight, Fang, Lei, Zhang, Bingqing, Chen, Steve, Latz, Eicke, Yin, Yiyuan, Luo, Yuling, Ma, Xiao-Jun
• Format: Journal Article
• Language: English
• Published: United States 02.06.2023

The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range across the proteome. We report a novel proteomic technology - NUcleic acid Linked Immuno-Sandwich Assay (NULISA™) - that incorpor...