Dietary protein shapes the profile and repertoire of intestinal CD4 + T cells

• Published in: bioRxiv : the preprint server for biology
• Main Authors: Lockhart, Ainsley, Reed, Aubrey, de Castro, Tiago Rezende, Herman, Calvin, Canesso, Maria Cecilia Campos, Mucida, Daniel
• Format: Journal Article
• Language: English
• Published: United States 13.04.2023

The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4 T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4 T cells. Indep...