Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19

The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, rangin...

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Published inPostgraduate medical journal Vol. 98; no. 1164; p. 765
Main Authors Çölkesen, Fatih, Kurt, Esma Kepenek, Vatansev, Hülya, Korkmaz, Celalettin, Çölkesen, Fatma, Yücel, Fatih, Yıldız, Eray, Evcen, Recep, Aykan, Filiz Sadi, Kılınç, Mehmet, Aytekin, Gökhan, Feyzioğlu, Bahadır, Doğan, Metin, Arslan, Şevket, Teke, Turgut, Keleş, Sevgi, Reisli, İsmail
Format Journal Article
LanguageEnglish
Published England 01.10.2022
Subjects
COVID-19
Female
Humans
Immunoglobulin A
Immunoglobulin G
Male
Memory B Cells
Middle Aged
Patient Acuity
Retrospective Studies
COVID-19
virology
immunology
general medicine
respiratory infections
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Summary:The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined. The median age of the patients was 50 (35-63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6-8) in deceased patients and 1 (0-2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG1 and IgG2 than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG1 levels were independent risk factors for mortality in patients with COVID-19. In the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels.
ISSN:1469-0756