Δ 8 -THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis

• Published in: International journal of molecular sciences Vol. 24; no. 7
• Main Authors: Gugliandolo, Agnese, Blando, Santino, Salamone, Stefano, Caprioglio, Diego, Pollastro, Federica, Mazzon, Emanuela, Chiricosta, Luigi
• Format: Journal Article
• Language: English
• Published: Switzerland 02.04.2023
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - genetics; Amyloid beta-Peptides - toxicity; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Neuroblastoma; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Peptide Fragments - pharmacology; Transcriptome; Unfolded Protein Response; unfolded protein response; Alzheimer’s disease; Δ8-THC; neuronal apoptosis

Alzheimer's disease (AD) represents the most common form of dementia, characterized by amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by neuroinflammation, the accumulation of misfolded protein, ER stress and neuronal apoptosis. It is of main importance to find n...