SARS-CoV-2 envelope protein attain K ac mediated dynamical interaction network to adopt 'histone mimic' at BRD4 interface

• Published in: Journal of biomolecular structure & dynamics Vol. 41; no. 24; p. 15305
• Main Authors: Agrahari, Ashish Kumar, Srivastava, Mitul, Singh, Mrityunjay, Asthana, Shailendra
• Format: Journal Article
• Language: English
• Published: England 2023
• Subjects: Bromodomain Containing Proteins; Cell Cycle Proteins - metabolism; COVID-19; Histones - chemistry; Humans; Lysine; Nuclear Proteins - chemistry; Peptides - metabolism; Protein Binding; SARS-CoV-2 - metabolism; Transcription Factors - chemistry; Tyrosine - metabolism; Water - metabolism; molecular mimicry; SARS-CoV-2; interaction mimicry; envelope protein; molecular dynamics simulation; protein–protein interaction; BRD4/BD1; Kac

Interface mimicry, achieved by recognition of host-pathogen interactions, is the basis by which pathogen proteins can hijack the host machinery. The envelope (E) protein of SARS-CoV-2 is reported to mimic the histones at the BRD4 surface via establishing the structural mimicry; however, the underlyi...