IgA nephropathy and granulomatosis with polyangiitis-overlap: a rare coexistence of two glomerular nephropathies with remission after steroids and rituximab

• Published in: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Vol. 40; no. 1
• Main Authors: Londrino, Francesco, Giuliani, Giovanni, Santostefano, Marisa, Baraldi, Olga, Mattiotti, Maria, Mangiulli, Marco, Tatangelo, Paola, Gambardella, Giorgia, Dominijanni, Sara, Napoli, Marianna, La Manna, Gaetano, Palumbo, Roberto
• Format: Journal Article
• Language: Italian
• Published: Italy 27.02.2023
• Subjects: Adult; Antibodies, Antineutrophil Cytoplasmic - therapeutic use; Glomerulonephritis; Glomerulonephritis, IGA - complications; Glomerulonephritis, IGA - drug therapy; Granulomatosis with Polyangiitis - complications; Granulomatosis with Polyangiitis - drug therapy; Humans; Kidney Glomerulus - pathology; Male; Rituximab - therapeutic use; Steroids; granulomatosis with polyangiitis; IgA nephropathy and granulomatosis with polyangiitis-overlap; ANCA-associated vasculitis; rituximab

Granulomatosis with polyangiitis (GPA) is an ANCA-positive systemic vasculitis that mainly involves lungs and kidneys. This condition rarely overlaps with other glomerulonephritides. A 42-year-old man with constitutional symptoms and haemophtoe was admitted to the Infectious Diseases department, whe...