Taraxasterol alleviates aflatoxin B 1 -induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy

• Published in: Ecotoxicology and environmental safety Vol. 251; p. 114546
• Main Authors: Sang, Rui, Ge, Bingjie, Li, Haifeng, Zhou, Hongyuan, Yan, Kexin, Wang, Wei, Cui, Qichao, Zhang, Xuemei
• Format: Journal Article
• Language: English
• Published: Netherlands 01.02.2023
• Subjects: Aflatoxin B1 - toxicity; Animals; Antioxidants - metabolism; Apoptosis; Autophagy; Chickens - metabolism; Glutathione - metabolism; Kelch-Like ECH-Associated Protein 1 - metabolism; Liver; Mammals - metabolism; NF-E2-Related Factor 2 - metabolism; Oxidative Stress; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; RNA, Messenger - metabolism; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Oxidative stress; Aflatoxin B; Liver damage; Broiler chickens; Taraxasterol

Aflatoxin B (AFB ) is the most dangerous and abundant mycotoxin, which is toxic to almost all animals, and poultry is more sensitive to AFB toxicity. Ingesting AFB -contaminated feed can cause significant liver damage and brings serious harm to poultry, which greatly restricts the development of the...