Current State of 44 Ti/ 44 Sc Radionuclide Generator Systems and Separation Chemistry

In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emis...

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Published inCurrent radiopharmaceuticals Vol. 16; no. 2; p. 95
Main Authors Schmidt, Christine E, Gajecki, Leah, Deri, Melissa A, Sanders, Vanessa A
Format Journal Article
LanguageEnglish
Published United Arab Emirates 2023
Subjects
Positron-Emission Tomography - methods
Radioisotopes
Radionuclide Generators
Radiopharmaceuticals
Scandium
Titanium
diagnostics
radioisotope production
titanium
Scandium
generators
radiolabeling
PET
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Abstract In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current Ti/ Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the Sc for potential PET radiopharmaceuticals.
AbstractList In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current Ti/ Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the Sc for potential PET radiopharmaceuticals.
Author Gajecki, Leah
Schmidt, Christine E
Sanders, Vanessa A
Deri, Melissa A
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  surname: Sanders
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  organization: Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USA
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Issue 2
Keywords diagnostics
radioisotope production
titanium
Scandium
generators
radiolabeling
PET
Language English
License Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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Snippet In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal...
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StartPage 95
SubjectTerms Positron-Emission Tomography - methods
Radioisotopes
Radionuclide Generators
Radiopharmaceuticals
Scandium
Titanium
Title Current State of 44 Ti/ 44 Sc Radionuclide Generator Systems and Separation Chemistry
URI https://www.ncbi.nlm.nih.gov/pubmed/36372922
Volume 16
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