Current State of 44 Ti/ 44 Sc Radionuclide Generator Systems and Separation Chemistry

In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emis...

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Bibliographic Details
Published inCurrent radiopharmaceuticals Vol. 16; no. 2; p. 95
Main Authors Schmidt, Christine E, Gajecki, Leah, Deri, Melissa A, Sanders, Vanessa A
Format Journal Article
LanguageEnglish
Published United Arab Emirates 2023
Subjects
Positron-Emission Tomography - methods
Radioisotopes
Radionuclide Generators
Radiopharmaceuticals
Scandium
Titanium
diagnostics
radioisotope production
titanium
Scandium
generators
radiolabeling
PET
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Summary:In recent years, there has been an increased interest in Ti/ Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current Ti/ Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the Sc for potential PET radiopharmaceuticals.
ISSN:1874-4729