Upregulated Ca 2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer's Disease

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 14
• Main Authors: Adeoye, Temitope, Shah, Syed I, Demuro, Angelo, Rabson, David A, Ullah, Ghanim
• Format: Journal Article
• Language: English
• Published: Switzerland 11.07.2022
• Subjects: Alzheimer Disease - metabolism; Animals; Calcium - metabolism; Endoplasmic Reticulum - metabolism; Neurotransmitter Agents - metabolism; IP3R; neuronal calcium signaling; synaptic transmission; depression; facilitation; neurotransmitter release; Alzheimer’s; endoplasmic reticulum; short-term plasticity; synchronous release; asynchronous release

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca influx through membrane-resident voltage-gated Ca channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensively present in axonal terminals of neurons and plays a m...