Cannabinoid CB 2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer's Disease

• Published in: Frontiers in pharmacology Vol. 13; p. 841766
• Main Authors: Ruiz de Martín Esteban, Samuel, Benito-Cuesta, Irene, Terradillos, Itziar, Martínez-Relimpio, Ana M, Arnanz, M Andrea, Ruiz-Pérez, Gonzalo, Korn, Claudia, Raposo, Catarina, Sarott, Roman C, Westphal, Matthias V, Elezgarai, Izaskun, Carreira, Erick M, Hillard, Cecilia J, Grether, Uwe, Grandes, Pedro, Grande, M Teresa, Romero, Julián
• Format: Journal Article
• Language: English
• Published: Switzerland 2022
• Subjects: CB2 receptor; amyloid; Alzheimer’s disease; cannabinoids; microglia

The distribution and roles of the cannabinoid CB receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in microglial cells, the CB receptor may be also expressed at low levels, yet biologically relevant, in other cell types such as neurons. It is acc...