A ratiometric fluorescent probe for detection of γ-glutamyl transpeptidase in blood serum and living cells

γ-Glutamyl transpeptidase (GGT) is one of the biomarker of cancer, hepatitis, and numerous other diseases. The accurate analysis of GGT is useful for the early diagnosis of these diseases. In this work, Probe 1, a ratiometric fluorescent probe based on 2,3,5,6-tetrafluoroterephthalonitrile, was desi...

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Published inSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 278; p. 121325
Main Authors Wang, Shuai, Liu, Weimin, Zheng, Xiuli, Ren, Haohui, Wu, Jiasheng, Li, Fan, Wang, Pengfei
Format Journal Article
LanguageEnglish
Published England 05.10.2022
Subjects
γ-Glutamyl transpeptidase
Cancer cells
Ratiometric fluorescent probe
Blood serum
Fluorescent imaging
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Abstract γ-Glutamyl transpeptidase (GGT) is one of the biomarker of cancer, hepatitis, and numerous other diseases. The accurate analysis of GGT is useful for the early diagnosis of these diseases. In this work, Probe 1, a ratiometric fluorescent probe based on 2,3,5,6-tetrafluoroterephthalonitrile, was designed for GGT detection. The results indicated that Probe 1 can sensitively and selectively detect GGT in phosphate buffered solution and complex biological systems (e.g., blood serum). Furthermore, Probe 1 has been successfully applied for ratiometric imaging of GGT in cancer cells and normal cells.
AbstractList γ-Glutamyl transpeptidase (GGT) is one of the biomarker of cancer, hepatitis, and numerous other diseases. The accurate analysis of GGT is useful for the early diagnosis of these diseases. In this work, Probe 1, a ratiometric fluorescent probe based on 2,3,5,6-tetrafluoroterephthalonitrile, was designed for GGT detection. The results indicated that Probe 1 can sensitively and selectively detect GGT in phosphate buffered solution and complex biological systems (e.g., blood serum). Furthermore, Probe 1 has been successfully applied for ratiometric imaging of GGT in cancer cells and normal cells.
Author Zheng, Xiuli
Ren, Haohui
Li, Fan
Wu, Jiasheng
Wang, Shuai
Wang, Pengfei
Liu, Weimin
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Keywords γ-Glutamyl transpeptidase
Cancer cells
Ratiometric fluorescent probe
Blood serum
Fluorescent imaging
Language English
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