Group IIA secreted phospholipase A 2 inhibition by elemolic acid as a function of anti-inflammatory activity

• Published in: Scientific reports Vol. 12; no. 1; p. 7649
• Main Authors: Giresha, Aladahalli S, Urs, Deepadarshan, Manjunatha, J G, Sophiya, P, Supreetha, B H, Jayarama, Shankar, Dharmappa, K K
• Format: Journal Article
• Language: English
• Published: England 10.05.2022
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Daboia; Edema - chemically induced; Edema - drug therapy; Inflammation - drug therapy; Mice; Phospholipases A2

Human group IIA secreted phospholipase A2 (GIIA) is a key enzyme in inflammatory reactions, worsening the condition of several chronic inflammatory diseases. The natural inhibitors of GIIA potentially block the production of inflammatory mediators. In the present study, elemolic acid, a triterpenoid...