N 6 -methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance

• Published in: Military medical research Vol. 9; no. 1; p. 19
• Main Authors: Lin, Xian, Wang, Feng, Chen, Jian, Liu, Jing, Lin, Yi-Bin, Li, Li, Chen, Chuan-Ben, Xu, Qin
• Format: Journal Article
• Language: English
• Published: England 14.04.2022
• Subjects: Adenosine - analogs & derivatives; Animals; beta Catenin - genetics; beta Catenin - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Drug Resistance, Neoplasm - genetics; Female; Humans; Mice; Neoplasm Recurrence, Local; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; RNA, Messenger; RNA-Binding Proteins - genetics; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Stemness; N 6-methyladenosine; Chemoresistance; Centromere protein K; Cervical cancer

Stemness and chemoresistance contribute to cervical cancer recurrence and metastasis. In the current study, we determined the relevant players and role of N -methyladenine (m A) RNA methylation in cervical cancer progression. The roles of m A RNA methylation and centromere protein K (CENPK) in cervi...