Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca 2+ signaling

• Published in: Molecular psychiatry Vol. 27; no. 5; p. 2470
• Main Authors: Allen, Megan, Huang, Ben S, Notaras, Michael J, Lodhi, Aiman, Barrio-Alonso, Estibaliz, Lituma, Pablo J, Wolujewicz, Paul, Witztum, Jonathan, Longo, Francesco, Chen, Maoshan, Greening, David W, Klann, Eric, Ross, M Elizabeth, Liston, Conor, Colak, Dilek
• Format: Journal Article
• Language: English
• Published: England 01.05.2022
• Subjects: Animals; Astrocytes - physiology; Autism Spectrum Disorder - genetics; Hippocampus - pathology; Mice; Neuronal Plasticity - physiology; Neurons - physiology; Synapses - physiology

The cellular mechanisms of autism spectrum disorder (ASD) are poorly understood. Cumulative evidence suggests that abnormal synapse function underlies many features of this disease. Astrocytes regulate several key neuronal processes, including the formation of synapses and the modulation of synaptic...