Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABA A receptors

• Published in: Behavioural brain research Vol. 428; p. 113832
• Main Authors: Souza, Adriana Jesus, Cortez, Isadora L, Silva, Nicole R, Pedrazzi, João Francisco C, Domingos, Luana B, Braga, Matheus Silva, Santos-Silva, Thamyris, Del-Bel, Elaine A, Resstel, Leonardo B M, Li, Guanguan, Mian, Md Yeunus, Sharmin, Dishary, Guimarães, Francisco S, Cook, James M, Gomes, Felipe V
• Format: Journal Article
• Language: English
• Published: Netherlands 25.06.2022
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Antipsychotic Agents; Benzodiazepines - pharmacology; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred C57BL; Receptors, GABA-A; GABA(A) receptors; SH-053–2′F-R-CH3; Schizophrenia; Depression; Anxiety; Excitatory-inhibitory balance; GL-II-73

Dysregulation of GABAergic neurotransmission has long been implicated in several psychiatric disorders, including schizophrenia, depression, and anxiety disorders. Alpha 5 subunit-containing GABA receptors (α5-GABA R), which are expressed mainly by pyramidal neurons in the hippocampus, have been pro...