Characterization of undescribed melanoma inhibitors from Euphorbia mauritanica L. cultivated in Egypt targeting BRAF V600E and MEK 1 kinases via in-silico study and ADME prediction

• Published in: Phytochemistry (Oxford) Vol. 198; p. 113154
• Main Authors: Essa, Ahmed F, El-Hawary, Seham S, Emam, Sherif E, Kubacy, Tahia M, El-Khrisy, Ezz El-Din A M, Younis, Inas Y, Elshamy, Abdelsamed I
• Format: Journal Article
• Language: English
• Published: England 01.06.2022
• Subjects: Animals; Caco-2 Cells; Diterpenes - chemistry; Diterpenes - pharmacology; Egypt; Euphorbia - chemistry; Hep G2 Cells; Humans; MAP Kinase Kinase 1 - metabolism; Melanoma - drug therapy; Melanoma - enzymology; Melanoma, Experimental - drug therapy; Melanoma, Experimental - enzymology; Mice; Molecular Docking Simulation; Molecular Structure; Proto-Oncogene Proteins B-raf - metabolism; Spectroscopy, Fourier Transform Infrared; Egypt; Euphorbia mauritanica L; Melanoma; Euphorbiaceae; Jatrophane; Molecular docking; Ent-abietane

Three undescribed diterpenes including two ent-abietanes, euphomauritanol A, and euphomauritanol B, and one jatrophane, euphomauritanophane A, in addition to eight previously described metabolites were isolated from the MeOH-CH Cl (1:1) extract of the Euphorbia mauritanica. The chemical structures o...