Influence of β 2 adrenergic receptor genotype on longitudinal measures of forced vital capacity in patients with Duchenne muscular dystrophy

• Published in: Neuromuscular disorders : NMD Vol. 32; no. 2; p. 150
• Main Authors: Kelley, Eli F, Cross, Troy J, McDonald, Craig M, Hoffman, Eric P, Bello, Luca
• Format: Journal Article
• Language: English
• Published: England 01.02.2022
• Subjects: Genotype; Humans; Muscular Dystrophy, Duchenne; Respiration; Signal Transduction; Vital Capacity; Beta2-adrenergic receptor; Duchenne muscular dystrophy; Forced vital capacity; Genotype; Respiratory

The progression of decline in forced vital capacity as percent predicated (FVC%p) is a strong indicator of worsening prognosis in patients with Duchenne muscular dystrophy (DMD). Evidence suggests that ß adrenergic (ADRB2) receptors may play a role in determining respiratory function, whereby more f...