Lipid-Based Nanoparticles for Targeted Delivery of the Anti-Cancer Drugs: A Review

Cancer is one of the main reasons for mortality worldwide. Chemotherapeutic agents have been effectively designed to increase certain patients' survival rates, but ordinarily designed chemotherapeutic agents necessarily deliver toxic chemotherapeutic drugs to healthy tissues, resulting in serio...

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Bibliographic Details
Published inCurrent drug delivery
Main Authors Khodaverdi, Hamed, Zeini, Maryam Shokrian, Moghaddam, Mehrdad Moosazadeh, Vazifedust, Soheil, Akbariqomi, Mostafa, Tebyanian, Hamid
Format Journal Article
LanguageEnglish
Published United Arab Emirates 17.01.2022
Subjects
Drug
Lipid-based Carriers
Nanoparticle
Cancer
Non structured lipid carriers
Targeted Delivery
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Summary:Cancer is one of the main reasons for mortality worldwide. Chemotherapeutic agents have been effectively designed to increase certain patients' survival rates, but ordinarily designed chemotherapeutic agents necessarily deliver toxic chemotherapeutic drugs to healthy tissues, resulting in serious side effects. Cancer cells can often acquire drug resistance after repeated dosing of current chemotherapeutic agents, restricting their efficacy. Given such obstacles, investigators have attempted to distribute chemotherapeutic agents using targeted drug delivery systems (DDSs), especially nanotechnology-based DDSs. Lipid-Based Nanoparticles (LBNPs) are a large and complex class of substances that have been utilized to manage a variety of diseases, mostly cancer. Liposomes seem to be the most frequently employed LBNPs, owing to their high biocompatibility, bioactivity, stability, and flexibility; howbeit Solid Lipid Nanoparticles (SLNs) and Non-structured Lipid Carriers (NLCs) have lately received a lot of interest. Besides that, there are several reports that concentrate on novel therapies via LBNPs to manage various forms of cancer. In the present research, the latest improvements in the application of LBNPs have been shown to deliver different therapeutic agents to cancerous cells and have been demonstrated LBNPs also can be a quite successful candidate in cancer therapy for subsequent use.
ISSN:1875-5704