The microglial P2Y 6 receptor mediates neuronal loss and memory deficits in neurodegeneration

• Published in: Cell reports (Cambridge) Vol. 37; no. 13; p. 110148
• Main Authors: Puigdellívol, Mar, Milde, Stefan, Vilalta, Anna, Cockram, Tom O J, Allendorf, David H, Lee, Jeffrey Y, Dundee, Jacob M, Pampuščenko, Katryna, Borutaite, Vilmante, Nuthall, Hugh N, Brelstaff, Jack H, Spillantini, Maria Grazia, Brown, Guy C
• Format: Journal Article
• Language: English
• Published: United States 28.12.2021
• Subjects: Amyloid beta-Peptides - toxicity; Animals; Female; Male; Memory Disorders - etiology; Memory Disorders - metabolism; Memory Disorders - pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia - metabolism; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Phagocytosis; Receptors, Purinergic P2 - physiology; tau Proteins - genetics; tau Proteins - metabolism; memory deficits; phagocytosis; Alzheimer’s disease; cell death; P2Y receptor; neurodegeneration; microglia
• ISSN: 2211-1247
• DOI: 10.1016/j.celrep.2021.110148

Microglia are implicated in neurodegeneration, potentially by phagocytosing neurons, but it is unclear how to block the detrimental effects of microglia while preserving their beneficial roles. The microglial P2Y receptor (P2Y R) - activated by extracellular UDP released by stressed neurons - is req...