Neuroprotective Roles of the Adenosine A 3 Receptor Agonist AST-004 in Mouse Model of Traumatic Brain Injury

• Published in: Neurotherapeutics Vol. 18; no. 4; p. 2707
• Main Authors: Bozdemir, Eda, Vigil, Fabio A, Chun, Sang H, Espinoza, Liliana, Bugay, Vladislav, Khoury, Sarah M, Holstein, Deborah M, Stoja, Aiola, Lozano, Damian, Tunca, Ceyda, Sprague, Shane M, Cavazos, Jose E, Brenner, Robert, Liston, Theodore E, Shapiro, Mark S, Lechleiter, James D
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Adenosine - metabolism; Adenosine - pharmacology; Animals; Astrocytes - metabolism; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - drug therapy; Brain Injuries, Traumatic - metabolism; Disease Models, Animal; Female; Gliosis - metabolism; Male; Mice; Mice, Inbred C57BL; Neuroprotection; Neuroprotective Agents - metabolism; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Mitochondrial metabolism; Astrocytes; Concussion treatment; ADORA3; ATP

Traumatic brain injury (TBI) remains one of the greatest public health concerns with increasing morbidity and mortality rates worldwide. Our group reported that stimulation of astrocyte mitochondrial metabolism by P2Y receptor agonists significantly reduced cerebral edema and reactive gliosis in a T...