The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP 2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients

• Published in: Journal of translational medicine Vol. 19; no. 1; p. 306
• Main Authors: Eaton-Fitch, Natalie, Cabanas, Hélène, du Preez, Stanley, Staines, Donald, Marshall-Gradisnik, Sonya
• Format: Journal Article
• Language: English
• Published: England 15.07.2021
• Subjects: Fatigue Syndrome, Chronic - drug therapy; Flow Cytometry; Humans; Interleukin-2; Killer Cells, Natural; TRPM Cation Channels; Myalgic Encephalomyelitis; Transient receptor potential melastatin 3; IL-2; Natural killer cells; Chronic Fatigue Syndrome; PIP2

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious multifactorial disorder. The origin remains ambiguous, however reduced natural killer (NK) cell cytotoxicity is a consistent immunological feature of ME/CFS. Impaired transient receptor potential melastatin 3 (TRPM3), a phospha...