nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish

• Published in: Journal of experimental biology
• Main Authors: Miyashita, Tetsuto, Baddam, Pranidhi, Smeeton, Joanna, Oel, A Phil, Natarajan, Natasha, Gordon, Brogan, Palmer, A Richard, Crump, J Gage, Graf, Daniel, Allison, W Ted
• Format: Journal Article
• Language: English
• Published: England 01.01.2020
• Subjects: Agnatha; Jaw; Skeletal remodeling; Developmental plasticity; Bapx; Nkx3.2; Zebrafish; Joint

The vertebrate jaw is a versatile feeding apparatus. To function, it requires a joint between the upper and lower jaws, so jaw joint defects are often highly disruptive and difficult to study. To describe the consequences of jaw-joint dysfunction, we engineered two independent null alleles of a sing...