Physalin B attenuates liver fibrosis via suppressing LAP2α-HDAC1 mediated deacetylation of GLI1 and hepatic stellate cell activation

• Published in: British journal of pharmacology
• Main Authors: Zhu, Xiaoyun, Ye, Shengtao, Yu, Dongke, Zhang, Yanqiu, Li, Jie, Zhang, Meihui, Leng, Yingrong, Yang, Ting, Luo, Jianguang, Chen, Xinlin, Zhang, Hao, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: England 17.04.2021
• Subjects: Physalin B; HDAC1; LAP2α; Acetylation; Liver fibrosis; GLI1

Liver fibrosis is one of the leading causes of morbidity and mortality worldwide of which no acceptable therapy exists. Accumulating evidence supports that glioma-associated oncogene homologue 1 (GLI1) is a potentially important therapeutic target for liver fibrosis. This study investigates the anti...