Cullin7 in tumor development: a novel potential anti-cancer target

• Published in: Neoplasma
• Main Authors: Li, Yumiao, Zang, Aiming, Fu, Jiejun, Jia, Youchao
• Format: Journal Article
• Language: English
• Published: Slovakia 24.02.2021

As a core scaffold protein, Cullin7 (Cul7) forms Skp1-Cullin-F-box (SCF) E3 ubiquitin ligase complexes with the regulator of cullins-1 (ROC1), S-phase kinase associated protein 1 (Skp1) and F-Box, and WD repeat domain containing 8 (Fbxw8). Alternatively, Cul7 can form a CRL7SMU1 complex with suppres...