The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

• Published in: Current drug targets Vol. 22; no. 13; p. 1524
• Main Authors: Shabgah, Arezoo G, Mohammadi, Hamed, Goleij, Pouya, Hedayati-Moghadam, Mahdiyeh, Salmaninejad, Arash, Navashenaq, Jamshid G
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2021
• Subjects: Cancer-Associated Fibroblasts - metabolism; Humans; Neoplasms - drug therapy; Neoplasms - genetics; RNA, Untranslated - physiology; cancer-associated fibroblasts; fibroblasts; lncRNA; miRNA; cancer; Non-coding RNA

Cancer-associated fibroblasts (CAFs) are senescent fibroblasts in tumor nest, which trigger a signaling center to remodel a desmoplastic tumor niche. CAF's functions in cancer are closely similar to myofibroblasts during the wound healing process. They can produce cytokines, enzymes, and protei...